Fri Jul 14 2023

103 articles - From Friday Jul 07 2023 to Friday Jul 14 2023

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Guidelines

Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…

J Neurogastroenterol Motil

2022 Seoul Consensus on Clinical Practice Guidelines for Functional Constipation.

The guidelines consist of 34 recommendations, including 3 concerning the definition and epidemiology of functional constipation, 9 regarding diagnoses, and 22 regarding managements. Clinicians (including primary physicians, general health professionals, medical students, residents, and other healthcare professionals) and patients can refer to these guidelines to make informed decisions regarding the management of functional constipation.

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Meta-analysis

meta-analyses and systematic reviews

Neurogastroenterol Motil

The role of histology in the diagnosis of non-erosive reflux disease: A systematic review and meta-analysis.

Although esophageal mucosal biopsies had poor sensitivity at diagnosing NERD, biopsies taken within 3 cm of the LES had higher sensitivity when pathologists reported upon eosinophils and dilated intraepithelial spaces.

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Original articles

RCT, clinical trials, retrospective studies, etc…

Aliment Pharmacol Ther

Clinical utility of liver fat quantification for determining cardiovascular disease risk among patients with type 2 diabetes.

While it is known that NAFLD and T2DM increase the risk of CVD among patients with T2DM, a higher liver fat content further increases CVD risk independent of age, gender, ethnicity and BMI. These findings raise the question whether liver fat quantification should be incorporated into risk calculators to further stratify those with higher CVD risk.

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Understanding colorectal cancer risk for symptomatic patients in primary care: A cohort study utilising faecal immunochemical tests and blood results in England.

FIT alone with a single cut-off is unlikely to be a panacea for optimising CRC diagnosis, as risk varies by FIT, age and anaemia when faecal haemoglobin levels are below 100 µg Hb/g. Tailored FIT cut-offs for investigation on a CRC pathway could reduce the number of investigations needed at a 3% CRC risk threshold.

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Am J Gastroenterol

Bowel Urgency in Ulcerative Colitis: Current Perspectives and Future Directions.

Patient-reported outcome measures developed to assess the severity of bowel urgency in ulcerative colitis are discussed alongside overviews of treatment options and clinical guidelines. Implications for the future management of ulcerative colitis from the perspective of bowel urgency are also explored.

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Higher Serrated Polyp Detection Rates are Associated with Lower Risk for Post Colonoscopy Colorectal Cancer: Data From the New Hampshire Colonoscopy Registry.

Endoscopists with higher SSLDR had lower risks for PCCRC. These data validate SSLDR as a clinically relevant quality measure.

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Lactated Ringers Use in the First 24 Hours of Hospitalization is Associated with Improved Outcomes in 999 Acute Pancreatitis Patients.

LR administration in the first 24 hours of hospitalization was associated with improved AP severity. A large scale randomized clinical trial is needed to confirm these findings.

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Quality of Tissue Samples Obtained by Endoscopic Ultrasound-Guided Liver Biopsy: A Randomized, Controlled Clinical Trial.

EUS-LB is safe and accurate and may be considered an alternative to percutaneous LB for the evaluation of parenchymal liver diseases.

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The clinical impact of obesity in patients with disorders of defecation: a cross-sectional study of 1,155 patients.

Obesity impacts specific defecatory (mainly FI) and prolapse symptoms and pathophysiologic findings (higher anal resting pressure, significant rectocele). Prospective studies are required to determine if obesity is a modifiable risk factor for FI and constipation.

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Clin Gastroenterol Hepatol

Outcome of biological therapies and small molecules in ulcerative proctitis: a Belgian multicenter cohort study.

Advanced therapies are also efficacious and safe in patients with ulcerative colitis limited to the rectum. Therefore, the inclusion of patients with UP in future randomized-controlled trials should be considered.

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Regional differences in clinical presentation and prognosis of patients with post-sustained virologic response (SVR) hepatocellular carcinoma.

Clinical characteristics, including early-stage detection, and prognosis of post-SVR HCC significantly differed across geographic regions. Surveillance utilization appears to be a high-yield intervention target to improve prognosis among patients with post-SVR HCC globally.

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Tumour necrosis factor inhibitors in inflammatory bowel disease and risk of immune mediated inflammatory diseases.

In two nationwide cohorts of IBD patients, anti-TNF therapy was associated with an increased risk of rheumatoid arthritis, psoriasis, and hidradenitis suppurativa.

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Gastroenterology

A NOVEL PEPTIDE PREVENTS ENTEROTOXIN- AND INFLAMMATION-INDUCED INTESTINAL FLUID SECRETION BY STIMULATING NHE3 ACTIVITY.

These findings suggest pharmacologic stimulation of NHE3 activity as an efficacious approach for the treatment of moderate/severe diarrheal diseases.

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Dynamics in liver stiffness measurements predict outcomes in advanced chronic liver disease.

Repeating LSM enables an individual and updated risk assessment for decompensation and liver-related mortality in ACLD.

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Incidence and Risk Factors for Hepatocellular Carcinoma in Cirrhosis: the Multi-center Hepatocellular Carcinoma Early Detection Strategy (HEDS) Study.

Thus far, this is the largest prospective and geographically diverse study of a United States cohort of patients with cirrhosis that validates known risk factors for HCC (gender, age, obesity, years with cirrhosis, family history of liver cancer, baseline AFP, albumin, and AST). The incidence of HCC was 2.4 % per 100 person years.

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Serum 25-hydroxyvitamin D levels and risk of colorectal cancer: an age-stratified analysis.

Serum 25(OH)D levels may have beneficial associations with the risk of developing CRC for both early-onset and late-onset disease.

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Gastrointest Endosc

Comparison of the efficacy and safety of an oral sulfate solution and 3-liter polyethylene glycol on bowel preparation before colonoscopy: a phase III multicenter randomized controlled trial.

The split-dose OSS regimen was not inferior to the split-dose 3-liter PEG regimen for the quality of bowel preparation in a Chinese adult population. The safety and acceptability of the two groups were similar.

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Medium-term clinical efficacy of endoscopic antireflux mucosectomy on laryngopharyngeal reflux: a retrospective, multicenter cohort study.

ARMS is effective for LPRD. The GEFV grade can predict the prognosis of surgery. ARMS is effective in GEFV grade I-III patients, but the effect is not exact in GEFV grade IV patients and may even be aggravated.

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Gut

Mepolizumab for treatment of adolescents and adults with eosinophilic oesophagitis: a multicentre, randomised, double-blind, placebo-controlled clinical trial.

Mepolizumab did not achieve the primary endpoint of improving dysphagia symptoms compared with placebo. While eosinophil counts and endoscopic severity improved with mepolizumab at 3 months, longer treatment did not yield additional improvement.

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Treatment of adenoma recurrence after endoscopic mucosal resection.

RRA after EMR of LNPCPs can be effectively treated using simple endoscopic techniques with long-term adenoma remission of >90%; only 16% required retreatment. Therefore, more technically complex, morbid and resource-intensive endoscopic or surgical techniques are required only in selected cases.

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J Neurogastroenterol Motil

An Optogenetics-based Approach to Regulate Colonic Contractions by Modulating the Activity of the Interstitial Cells of Cajal in Mice.

Our study demonstrates a potentially feasible approach to stimulate the activity of ICC by optogenetics. The colonic motor patterns of muscle strips, especially LFHA contractions, can be regulated by 470 nm light via ChR2, which is expressed in ICC.

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Comparison of Diagnosis of Esophageal Motility Disorders by Chicago Classification Versions 3.0 and 4.0.

CC v4.0 is more rigorous than CC v3.0 for the diagnosis of EGJOO and IEM and diagnoses achalasia more accurately by using provocative tests and FLIP. Further studies on the treatment outcomes following diagnosis with CC v4.0 are needed.

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Effect of Helicobacter pylori Eradication on Body Weight: A Multicenter Propensity Score-matched Analysis in Korea.

The overall BMI change was not significantly different between the HPE and non-HPE groups, but patients with low BMI showed a tendency to gain weight after HPE. Triglyceride levels increased after HPE with marginal significance.

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Ethnic Differences in Anorectal Manometry Findings in Patients With Fecal Incontinence: Results From a Multiethnic Cohort According to the London Classification.

Ethnicity impacts ARM findings in patients with FI. The reason for this is unclear and future studies on ethnically diverse populations evaluating the clinical relevance of these findings are warranted.

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Extended Wireless pH Monitoring Significantly Increases Gastroesophageal Reflux Disease Diagnoses in Patients With a Normal pH Impedance Study.

WPM increases GERD diagnostic yield in patients with a negative MII-pH selected for further testing based on clinical suspicion. Further studies are needed to assess the role of WPM as a first line investigation in patients with GERD symptoms.

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Gastroesophageal Reflux Characteristics in Supragastric Belching Patients With Positive Versus Negative pH Monitoring: An Evidence of Secondary Gastroesophageal Reflux Disease From Excessive Belching.

In patients with GERD and SGB, the number of SGBs positively correlates with the number of reflux episodes preceded by SGBs. Identifying and managing SGB may be beneficial and more likely to improve GERD.

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Natural History of Chronic Intestinal Pseudo-obstruction and Need for Palliative Care.

CIPO is a rare, severe, and under-recognized disease. Standardization of treatment strategies, including palliative care and psychiatric interventions, is desired.

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Proton Pump Inhibitor-unresponsive Laryngeal Symptoms Are Associated With Psychological Comorbidities and Sleep Disturbance: A Manometry and Impedance-pH Monitoring Study

PPI-refractory laryngeal symptoms are mostly associated with psychological comorbidities and sleep disturbances. Recognition of these psychosocial comorbidities may help optimize management in these patients.

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Stigma and Efficacy of Zhizhu Kuanzhong Capsules Versus Doxepin in the Treatment of Refractory Functional Dyspepsia: A Randomized Controlled Trial.

ZZKZ is superior to doxepin in alleviating stigma and medication non-adherence, with comparable efficacy in improving dyspeptic symptoms and psychological condition of patients with rFD.

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Neurogastroenterol Motil

Co-occurrence of fecal incontinence with constipation or irritable bowel syndrome indicates the need for personalized treatment.

The prevalence of IBS-associated FI, constipation-associated FI, and isolated FI is comparably high. It is important to diagnose and target the cause of FI to provide personalized and cause-targeting care instead of treating only the FI symptoms.

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Distinctive gastrointestinal motor dysfunction in patients with MNGIE.

MNGIE patients exhibit a characteristic motor dysfunction, particularly of the small bowel, even in patients with mild digestive symptoms and in the absence of morphological signs of intestinal failure. Since symptoms are not predictive of objective findings, early investigation is indicated.

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Downregulation of BDNF-TrkB signaling may contribute to the colonic motility disorders in mice with streptozocin-induced diabetes.

Downregulation of BDNF/TrkB signaling and reduced SP release from the colon may contribute to the colonic hypomotility associated with type 1 diabetes. Brain-derived neurotrophic factor supplementation may have therapeutic potential for diabetes-related constipation.

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Factors affecting the outcome of fecal microbiota transplantation for patients with irritable bowel syndrome.

Administrating transplant to the small intestine had a long-term higher response rate than that administrated to the large intestine, and led to long-term colonization of beneficial bacteria. Repeating FMT had more effect on symptoms and quality of life than a single FMT. ( NCT04236843).

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First study to assess the reliability of commonly used pain scales in children with disorders of gut-brain interaction.

This is the first study to assess the most used AP scales in children with DGBIs. It supports the Rome IV recommendations on using the VAS and NRS scales. It also suggests that FPS-R, that was not part of Rome IV, can also be used in RCTs. Congruent with the biopsychosocial model, there was a weaker correlation between AP measures and the global question. This suggests that the global question measures more domains than AP alone and that it should also be incorporated in DGBIs RCTs in children.

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Radiographic and histopathological study of gastrointestinal dysmotility in lipopolysaccharide-induced sepsis in the rat.

Using radiographic, noninvasive methods for the first time, we show that systemic LPS causes dose-, time-, and organ-dependent GI motor effects. Sepsis-induced GI dysmotility is a complex condition whose management needs to take its time-dependent changes into account.

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The clinical effect of benesco™ on reflux symptoms: A double-blind randomized placebo-controlled trial.

In our trial benesco™ showed no significant benefit over placebo at group level.

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The impact of primary peristalsis, contractile reserve, and secondary peristalsis on esophageal clearance measured by timed barium esophagogram.

Primary peristalsis, contractile reserve, and secondary peristalsis were associated with abnormal esophageal retention as measured by TBE. Added benefit was observed when applying comprehensive models to incorporate primary and secondary peristalsis supporting their complementary application.

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Reviews&Editorials

Plenty of the editorials are available as full text through the publisher website using the provided link

Clin Gastroenterol Hepatol

Intraductal papillary mucinous neoplasms in high-risk individuals: True, true, and related?

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Gastroenterology

Dressing Up an Old Friend in New Clothes: A New Approach to Measuring Adenoma Detection Rate.

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J Hepatol

Palliative clinical trials in advanced chronic liver Disease: challenges and opportunities.

We identify barriers and facilitators and offer guidance on addressing these challenges. We hope that this will reduce the inequity in palliative care provision in advanced chronic liver disease.

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J Neurogastroenterol Motil

Do Proton Pump Inhibitor-refractory Laryngeal Symptoms Represent a True Acid-related Disease?

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What Is the Diagnostic Accuracy of Chicago Classification Version 4.0 and the Difference From Version 3.0 in Diagnosing Esophageal Motility Disorders?

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Neurogastroenterol Motil

Psychosocial factors impacting antegrade continence enema outcomes in pediatric patients.

Psychosocial pre-procedure evaluations could help to inform eligibility for the procedure as well as interventions to enhance outcomes for children at increased risk for poor outcomes or complications from ACE. Age, psychiatric symptoms, and adherence to the ACE flush regimen were some of the factors identified in the literature as impacting ACE outcomes; however, there is limited research in this area.

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Miscellaneous

misc publications eg case reports, tools of the trade, images of the month, etc…

Am J Gastroenterol

Calendar of Courses, Symposiums and Conferences.

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Immune-Checkpoint Inhibitors in the Hepatitis C-Infected Patient: To Use or Not to Use?

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Nothing Compares to U-padacitinib.

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Clin Gastroenterol Hepatol

A Practical Approach to Disseminating Gastroenterology Education Scholarship.

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Endoscopy

A loop cutter is an ideal gripper for endoscopic removal of press-through-package sheets.

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A nerve-preserving strategy for endoscopic submucosal dissection of superficial pharyngeal cancers.

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A novel method for intratunnel closure of mucosal injuries during peroral endoscopic myotomy using standard endoclips.

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An airbag cap specially designed for the removal of sharp, deeply embedded foreign bodies: a new method of cap-assisted endoscopy.

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Cholangioscopy-directed basket extraction of bile duct stones in a pregnant patient.

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Cold snare and ablation technique for endoscopic mucosal resection of incompletely resected large laterally spreading tumors.

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Colorectal gel immersion endoscopic submucosal dissection using the tunneling method.

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Competency assessment: a journey of lifelong learning.

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Compression from an enlarged spleen in decompensated cirrhosis mimicking the appearance of fundal varices.

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Diverticular peroral endoscopic myotomy: management of a complex epiphrenic diverticulum.

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Double soft-tipped guidewire facilitating the rendezvous technique for ERCP.

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Dual-endoscopy detection for an esophageal-jejunal anastomotic fistula.

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Easier removal of a gastrointestinal stromal tumor using a new detachable snare-assisted traction technique.

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Efficacy and cost-effectiveness of a novel dual gasping forceps-assisted over-the-scope clip inverted closure after gastric endoscopic full-thickness resection.

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Endoscopic removal of an extraluminal gastrointestinal stromal tumor recurrence located on the surgical stapler line at gastroesophageal junction.

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Endoscopic submucosal dissection for early gastric cancer, using a disposable endoscope.

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Endoscopic submucosal dissection of a laterally spreading tumor totally invading a deep sigmoidal diverticulum using an adaptive traction strategy.

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Endoscopic submucosal dissection of gastric neoplasms with severe fibrosis using a new thin-therapeutic endoscope and a dedicated conical cap.

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Endoscopic ultrasound-guided placement of fiducial markers for stereotactic body radiation therapy of pancreatic metastases from renal cell carcinoma.

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Endoscopic ultrasound-guided portal pressure gradient measurement: improving safety and overcoming technical difficulties.

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Gastric antral defect closure after endoscopic submucosal dissection with the reopenable clip-over-the-line method using a multibending scope.

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Guidewire malposition outside the bile duct during endoscopic ultrasound-guided hepaticogastrostomy.

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Large-balloon anchor technique for endoscopic retrograde cholangiopancreatography in a patient with esophageal hiatal hernia.

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Novel method combining endoscopic band ligation and clipping for hemostasis of colonic diverticular bleeding.

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Salvage endoscopic submucosal resection for residual esophageal superficial cancer involving a stenotic anastomosis: a challenging but desirable indication.

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Small-bowel B-cell lymphoma presenting as autoimmune hemolytic anemia and severe obscure gastrointestinal bleeding.

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Successful endoscopic submucosal dissection for early gastric cancer involving the pyloric ring using a combination of water and gel immersion with the tunneling method.

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Successful endoscopic treatment of multiple large intrahepatic bile duct stones with benign choledochojejunal anastomotic stenosis.

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Use of a novel re-openable endoclip for the closure of a large mucosal defect after endoscopic submucosal dissection.

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Use of a transparent cap with a slit facilitates endoscopic injection sclerotherapy of esophageal varices.

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Use of mechanical lithotripter to assist in the endoscopic removal of an impacted long chicken bone in sigmoid diverticula.

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Gastroenterology

Trends in Medicare Spending on Oral Medications for Hepatitis B from 2013 to 2020.

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Gastrointest Endosc

"Two for One"; Histologic Diagnosis of Helicobacter pylori during EUS-guided Liver Biopsy.

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A disappeared fish bone.

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A rare cause of rectal bleeding.

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Aeromonas hydrophila-associated cecal ulcer with noncaseating epithelioid cell granulomas.

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Diagnosis of Gastroduodenal Artery Pseudoaneurysm on Endoscopic Ultrasound Doppler.

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Diagnosis of Tuberculous Pericarditis with Transgastric EUS Fine Needle Aspiration.

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Heartburn from a Neo-Acid Pocket Formed by a Laparoscopic Gastric Band.

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In Memoriam: Stuart Sherman MD, MASGE 1955-2023.

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Isolated gastric varices resulting from a wandering spleen.

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Migrating gastrostomy tube.

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Non-invasive endoscopic therapy of gourd-shaped appendix stenosis: An easier and effective path to follow.

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Pancreatic Cystic Lesion: Appearances can be Deceptive!

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Post-traumatic Pancreaticobiliary Fistula Associated with an Intraductal Papillary Mucinous Neoplasm.

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Splenic artery collateral masquerading as a gastric varix post splenic trauma.

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Treatment of gallstone ileus by balloon-enteroscopy guided laser-lithotripsy.

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Letters&Replies

Letters to the editors and authors’ replies

Clin Gastroenterol Hepatol

Re: Targeting Colorectal Advanced Neoplasia in Asia-Pacific or Locally: Why the Score Name Matters.

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Gastroenterology

Factors Associated with The Influence of Liver Fibrosis Should Be Fully Considered.

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Hemostatic powder in gastrointestinal tumor bleeding: Are we there yet?

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The SOX9 Expression Pattern and Its Prognosis in Gastric Cancer Should be Fully Evaluated.

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Gut

Mendelian randomisation analysis reveals the possible causal relationship between infections, microbiota and clinical disease.

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Microbiome variance of the small bowel in Crohn's disease.

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J Hepatol

Which risk model can better predict hepatocellular carcinoma in hepatitis B patients with an antiviral treatment duration of over one year ?

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J Neurogastroenterol Motil

Autonomic Dysfunction and Somatization in Young Patients With Irritable Bowel Syndrome and Mitral Valve Prolapse Syndrome.

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The Use of Intraoperative Esophageal Functional Luminal Imaging Probe for Prediction of Therapeutic Outcomes in Achalasia Patients.

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